Dianemycin
Cat. No.：YN250030
| 产品名称: | Dianemycin |
| CAS No.: | 35865-33-9 |
| Chemical Name: | (2S,4R,6E,8S)-8-[(2S,2′R,4′S,5R,5′S,7R,7′R,8R,9S,9′S,10′R)-9-hydroxy-2,4′,8,10′-tetramethyl-2′-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9′-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7′-bi-1,6-d |
| Synonyms: | Nanchangmycin free acid |
| 分子量: | 867.11 |
| 分子式: | C₄₇H₇₈O₁₄ |
| SMILES: | C[C@H]1[C@@]2(O[C@]([C@@]3([H])O[C@](O)([C@H](C)C[C@@H]3C)CO)([H])C[C@@H]2C)O[C@]([C@]4(O[C@]5(O[C@]([C@H](C)[C@@H](O)C5)([H])[C@@H](C)/C=C(C)/C([C@H](C)C[C@H](C)C(O)=O)=O)CC4)C)([H])C[C@@H]1O[C@@]6([H])O[C@@H]([C@@H](OC)CC6)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dianemycin (Nanchangmycin free acid) 由Streptomyces nanchangensisNS3226 产生的一种聚醚抗生素，抑制革兰氏阳性菌。Nanchangmycin 也是一种抗 Zika 病毒的广谱抗病毒药物。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Sun, Y., Zhou, X., Dong, H., et al.A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycinChem. Biol.10(5),431-441(2003)
Liu, T., Lin, X., Zhou, X., et al.Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycinChem. Biol.15(5),449-458(2008)
Rausch, K., Hackett, B., Weinbren, N.R., S., et al.Screening bioactives reveals nanchangmycin as a broad spectrum antiviral active against Zika virusCell Rep.18(3),804-815(2017)
