Nosiheptide
Cat. No.：YN250145
CAS No. ：56377-79-8
| 产品名称: | Nosiheptide |
| CAS No.: | 56377-79-8 |
| Chemical Name: | N-[1-(aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4] |
| Synonyms: | 那西肽; Multhiomycin; RP 9671 |
| 分子量: | 1222.36 |
| 分子式: | C₅₁H₄₃N₁₃O₁₂S₆ |
| SMILES: | OC1=C(C2=NC(C(NC(C(N)=O)=C)=O)=CS2)N=C(C3=CSC(C4NC(C5=CSC(C(CC(C(OCC6=C7C(C)=C(NC7=CC=C6)C(SC4)=O)=O)O)NC(C8=CSC(/C(NC(C(C(O)C)NC(C9=CSC%10=N9)=O)=O)=C\C)=N8)=O)=N5)=O)=N3)C%10=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nosiheptide (Multhiomycin) 是一种由Streptomyces actuosus产生的硫肽抗生素，可抑制细菌蛋白质的合成，并在独特的大环核上具有独特的吲哚侧环系统和区域特异性羟基，已被广泛用作动物生长的饲料添加剂。 |
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Cundliffe, E., and Thompson, J.The mode of action of nosiheptide (multhiomycin) and the mechanism of resistance in the producing organismJ. Gen. Microbiol.126(1),185-192(1981)
Yu, Y., Duan, L., Zhang, Q., et al.Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide frameworkACS Chem. Biol.4(10),855-864(2009)
Haste, N.M., Thienphrapa, W., Tran, D.N., et al.Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureusJ. Antibiot. (Tokyo)65(12),593-598(2012)
