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6-Diazo-5-oxo-L-nor-Leucine

Cat. No.:YN250158

  • CAS No. :157-03-9

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    • 参考文献
    • 产品名称: 6-Diazo-5-oxo-L-nor-Leucine
      CAS No.: 157-03-9
      Chemical Name: 6-diazo-5-oxo-L-norleucine
      Synonyms:L-6-Diazo-5-oxonorleucine; DON
      分子量:171.15
      分子式:C₆H₉N₃O₃
      SMILES:N[C@@H](CCC(C=[N+]=[N-])=O)C(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: L-6-Diazo-5-oxonorleucine (L-6-Diazo-5-oxonorleucine) 是一种谷氨酰胺拮抗剂,其Ki值为 6 μM。L-6-Diazo-5-oxonorleucine 具有镇痛、抗菌、抗病毒和抗癌作用。L-6-Diazo-5-oxonorleucine 在体外表现出遗传毒性。L-6-Diazo-5-oxonorleucine 能降低肿瘤细胞的自我更新能力和转移能力 。
      IC50和靶点:
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    • Willis, R.C., and Seegmiller, J.E.The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblastJ. Cell Physiol.93,375-382(1977)

      Thangavelu, K., Chong, Q.Y., Low, B.C., et al.Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA)Sci. Rep.4,1-7(2014)

      Thomas, A.G., Rojas, C., Tanega, C., et al.Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitorsBiochem. Biophys. Res. Commun.438(2),243-248(2013)

      Botman, D., Tigchelaar, W., and Van Noorden, C.J.F.Determination of phosphate-activated glutaminase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry)J. Histochem. Cytochem.62(11),813-826(2014)

      Greene, R.M., and Kochhar, D.M.Limb development in mouse embryos: Protection against teratogenic effects of 6-diazo-5-ox-ʟ-norleucine (DON) in vivo and in vitroJ. Embryol. Exp. Morphol.33(2),355-370(1975)

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