Pretomanid
Cat. No.：YN250163
CAS No. ：187235-37-6
| 产品名称: | Pretomanid |
| CAS No.: | 187235-37-6 |
| Chemical Name: | (6S)-6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine |
| Synonyms: | PA-824; (S)-PA 824 |
| 分子量: | 359.26 |
| 分子式: | C₁₄H₁₂F₃N₃O₅ |
| SMILES: | FC(F)(F)OC(C=C1)=CC=C1CO[C@@H]2COC3=NC([N+]([O-])=O)=CN3C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pretomanid (PA-824) 是一种抗生素，可用于肺部多重耐药性结核病的研究。Pretomanid 对结核病 (MTB) 具有亚微摩尔作用活性。Pretomanid 对 MTB 泛敏感和抗 Rifampin 的临床分离株的 MIC 值为 0.015 至 0.25 μg/mL。 |
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Singh, R., Manjunatha, U., Boshoff, H.I.M., et al.PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO releaseScience322(5906),1392-1395(2008)
Stover, C.K., Warrener, P., VanDevanter, D.R., et al.A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosisNature405(6789),962-966(2000)
Lenaerts, A.J., Gruppo, V., Marietta, K.S., et al.Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo modelsAntimicrob. Agents Chemother.49(6),2294-2301(2005)
