Herbimycin A
Cat. No.：YN250166
CAS No. ：70563-58-5
| 产品名称: | Herbimycin A |
| CAS No.: | 70563-58-5 |
| Chemical Name: | 17-demethoxy-15R-methoxy-11-O-methyl-geldanamycin |
| Synonyms: | Antibiotic Tan 420F; Herbimycin; Herbimycin A |
| 分子量: | 574.66 |
| 分子式: | C₃₀H₄₂N₂O₉ |
| SMILES: | CO[C@H]([C@H](C[C@@H]([C@@H]([C@H](/C=C([C@@H]1OC(N)=O)\C)C)OC)OC)C)C(C(C(NC(/C(C)=C/C=C\[C@@H]1OC)=O)=C2)=O)=CC2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Herbimycin A, an ansamycinantibiotic, acts as aSrc family kinaseinhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60v-srcand p210BCR-ABL. Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits an |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Omura, S., Iwai, Y., Takahashi, Y., et al.Herbimycin, a new antibiotic produced by a strain of StreptomycesJ. Antibiot. (Tokyo)32(4),255-261(1979)
Uehara, Y., and Fukazawa, H.Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinasesMethods Enzymol.201,371-379(1991)
Blagosklonny, M.V.Hsp-90-associated oncoproteins: Multiple targets of geldanamycin and its analogsLeukemia16(4),455-462(2002)
Fukazawa, H., Li, P.M., Yamamoto, C., et al.Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitroBiochem. Pharmacol.42(9),1661-1671(1991)
Fan, T.P.D., Jaggar, R., and Bicknell, R.Controlling the vasculature: Angiogenesis, anti-angiogenesis and vascular targeting of gene therapyTrends Pharmacol. Sci.16(2),57-66(1995)
Ogina, S., Tsuruma, K., Uehara, T., et al.Herbimycin A abrogates nuclear factor-κB activation by interacting preferentially with the IκB kinase β subunitMol. Pharmacol.65(6),1344-1351(2004)
Park, D.J., Min, H.K., and Rhee, S.G.IgE-induced tyrosine phosphorylation of phospholipase C-γ1 in rat basophilic leukemia cellsJ. Biol. Chem.266(36),24237-24240(1991)
Buro, C., Oliveira, K.C., Lu, Z., et al.Transcriptome analyses of inhibitor-treated schistosome females provide evidence for cooperating Src-kinase and TGFβ receptor pathways controlling mitosis and eggshell formationPLoS Pathog.9(6),e1003448(2013)
Whitesell, L., Mimnaugh, E.G., De Costa, B., et al.Inhibition of heat shock protein Hsp90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformationProc. Natl. Acad. Sci. USA91(18),8324-8328(1994)
