Clotrimazole
Cat. No.：YN250170
| 产品名称: | Clotrimazole |
| CAS No.: | 23593-75-1 |
| Chemical Name: | 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole |
| Synonyms: | 克霉唑 |
| 分子量: | 344.84 |
| 分子式: | C₂₂H₁₇ClN₂ |
| SMILES: | ClC1=CC=CC=C1C(N2C=CN=C2)(C3=CC=CC=C3)C4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Clotrimazole是咪唑衍生物，有抗真菌活性，是P450抑制剂。Clotrimazole 还具有抗菌活性。 |
| IC50和靶点: | |
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Burgess, M.A., and Bodey, G.P.Clotrimazole (Bay b 5097): In vitro and clinical pharmacological studiesAntimicrob. Agents Chemother.2(6),423-426(1972)
Shadomy, S.In vitro antifungal activity of clotrimazole (Bay b 5097)Infect. Immun.4(2),143-148(1971)
Waitz, J.A., Moss, E.L., and Weinstein, M.J.Chemotherapeutic evaluation of clotrimazole [Bay b 5097, 1 (o-chloro-α-α-diphenylbenzyl) imidazole]Appl. Microbiol.22(5),891-898(1971)
Fromtling, R.A.Overview of medically important antifungal azole derivativesClin. Microbiol. Rev.1(2),187-217(1988)
Warrilow, A.G., Melo, N., Martel, C.M., et al.Expression, purification, and characterization of Aspergillus fumigatus sterol 14-a demethylase (CYP51) isoenzymes A and BAntimicrob. Agents Chemother.54(10),4225-4234(2010)
Pegoraro, S., Lang, M., Dreker, T., et al.Inhibitors of potassium channels Kv1.3 and IK-1 as immunosuppressantsBioorg. Med. Chem. Lett.19(8),2299-2304(2009)
