Chrysomycin B
Cat. No.：YN250191
CAS No. ：83852-56-6
| 产品名称: | Chrysomycin B |
| CAS No.: | 83852-56-6 |
| Chemical Name: | 4-(6-deoxy-3-C-methyl-β-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one |
| Synonyms: | MAC-545496,MAC 545496，MAC545496 |
| 分子量: | 496.51 |
| 分子式: | C₂₇H₂₈O₉ |
| SMILES: | O=C1C2=CC(C)=CC(OC)=C2C3=CC(OC)=C4C(O)=CC=C([C@H]5[C@@H]([C@]([C@H]([C@@H](C)O5)O)(C)O)O)C4=C3O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Chrysomycin B is anantibioticisolated from a strain of Streptomyces. Chrysomycin B causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibitstopoisomerase II. Chrysomycin B suppresses the growth of transplantable tumors in mice. |
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Strelitz, F., Flon, H., and Asheshov, I.N.Chrysomycin: A new antibiotic substance for bacterial virusesJ. Bacteriol.69(3),280-283(1955)
Weiss, U., Yoshihira, K., Highet, R.J., et al.The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin AJ. Antibiot. (Tokyo)35(9),1194-1201(1982)
Matson, J.A., Rose, W.C., Bush, J.A., et al.Antitumor activity of chrysomycins M and VJ. Antibiot. (Tokyo)42(9),1446-1448(1989)
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Lorico, A., and Long, B.H.Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase IIEur. J. Cancer29A(14),1985-1991(1993)
Matsumoto, A., and Hanawalt, P.C.Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblastsCancer Res.60(14),3921-3926(2000)
