Monactin
Cat. No.：YN250195
CAS No. ：7182-54-9
| 产品名称: | Monactin |
| CAS No.: | 7182-54-9 |
| Chemical Name: | (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-5-ethyl-2,11,14,20,23,29,32-heptamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone |
| Synonyms: | |
| 分子量: | 750.96 |
| 分子式: | C₄₁H₆₆O₁₂ |
| SMILES: | CC[C@@H](OC([C@@H]([C@H]1O[C@@](C[C@@H](OC([C@H]([C@@](CC2)([H])O[C@@]2([H])C3)C)=O)C)([H])CC1)C)=O)C[C@]4([H])O[C@@]([C@@H](C(O[C@H](C[C@@]5([H])O[C@H]([C@H](C(O[C@@H]3C)=O)C)CC5)C)=O)C)([H])CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Monactin 是一种抗生素，也是单价阳离子 (包括钾、钠和锂) 的非选择性离子载体。Monactin 是从链霉菌中分离出来，并具有抗增殖活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Beck, J., Gerlach, H., Prelog, V., et al.Metabolic products of actinomycetes. XXXV. Constitution of the macrotetrolides, monactin, dinactin, and trinactinHelv. Chim. Acta45,620-630(1962)
Harold, F.M., and Baarda, J.R.Effects of nigericin and monactin on cation permeability of Streptococcus faecalis and metabolic capacities of potassium-depleted cellsJ. Bacteriol.95(3),816-823(1968)
Shaw, P.D.Nonactin and Related AntibioticsAntibiotics (USSR)1,649-650(1967)
Meyers, E., Pansy, F.E., Perlman, D.H., et al.The in vitro activity of nonactin and its homologs, monactin, dinactin, and trinactinJ. Antibiot. (Tokyo)18,128-129(1965)
Graven, S.N., Lardy, H.A., and Estrada-O, S.Antibiotics as tools for metabolic studies. 8. Effect of nonactin homologs on alkali metal cation transport and rate of respiration in mitochondriaBiochem.6(2),365-371(1967)
Tamai, Y., Toume, K., Arai, M.A., et al.Nonactin and related compounds found in a screening program for Wnt signal inhibitory activityHeterocycles84(2),1245-1250(2012)
