Actinonin
Cat. No.：YN250231
CAS No. ：13434-13-4
| 产品名称: | Actinonin |
| CAS No.: | 13434-13-4 |
| Chemical Name: | (2R)-N4-hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-butanediamide |
| Synonyms: | (R)-N4-Hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide;(-)-Actinonin;ACTINONIN;Actinonin;Butanediamide,N4-hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methyl...;Butanediamid |
| 分子量: | 385.50 |
| 分子式: | C₁₉H₃₅N₃O₅ |
| SMILES: | O=C(N[C@H](C(N1[C@H](CO)CCC1)=O)C(C)C)[C@H](CCCCC)CC(NO)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Actinonin ((-)-Actinonin) 是一种由放线菌产生的天然抗菌剂。Actinonin 抑制氨肽酶 M，氨肽酶 N 和亮氨酸氨肽酶。Actinonin 是一种有效的可逆肽去甲酰基酶 (PDF) 抑制剂，Ki为 0.28 nM。Actinonin 还抑制MMP-1，MMP-3，MMP-8，MMP-9和hmeprin α的Ki值分别为 300 nM，1,700 nM，190 nM，330 nM 和 20 nM。Actinonin 是一种凋亡诱导剂，具有抗增殖和抗肿瘤活性。 |
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Kruse, M.N., Becker, C., Lottaz, D., et al.Human meprin α and β homo-oligomers: Cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitorsBiochem. J.378(1),383-389(2004)
Lee, M.D., She, Y., Soskis, M.J., et al.Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibioticsJ. Clin. Invest.114(8),1107-1116(2004)
