Anhydrotetracycline hydrochloride
Cat. No.：YN250272
CAS No. ：13803-65-1
| 产品名称: | Anhydrotetracycline hydrochloride |
| CAS No.: | 13803-65-1 |
| Chemical Name: | 4-(dimethylamino)-1,4S,4aS,5,12,12aS-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide, monohydrochloride |
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| 分子量: | 462.88 |
| 分子式: | C₂₂H₂₃ClN₂O₇ |
| SMILES: | O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])CC3=C(C([C@@]21O)=O)C(O)=C4C(O)=CC=CC4=C3C)N.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Anhydrotetracycline hydrochloride 是一种四环素的生物合成前体，是一种有效的竞争性的四环素破坏酶 (tetracycline destructase enzymes) 广谱抑制剂。Anhydrotetracycline hydrochloride 是真核细胞中四环素控制的基因表达系统的效应子。 |
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Gossen, M., and Bujard, H.Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cellsNucleic Acids Res.21(18),4411-4412(1993)
Kamionka, A., Bogdanska-Urbaniak, J., Scholz, O., et al.Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressorNucleic Acids Res.32(2),842-847(2004)
Resch, M., Striegl, H., Henssler, E.M., et al.A protein functional leap: How a single mutation reverses the function of the transcription regulator TetRNucleic Acids Res.36(13),4390-4401(2008)
Degenkolb, J., Takahashi, M., Ellestad, G.A., et al.Structural requirements of tetracycline-Tet repressor interaction: Determination of equilibrium binding constants for tetracycline analogs with the Tet repressorAntimicrob. Agents Chemother.35(8),1591-1595(1991)
Rasmussen, B., Noller, H.F., Daubresse, G., et al.Molecular basis of tetracycline action: Identification of analogs whose primary target is not the bacterial ribosomeAntimicrob. Agents Chemother.35(11),2306-2311(1991)
