Camalexin
Cat. No.：YN250279
CAS No. ：135531-86-1
| 产品名称: | Camalexin |
| CAS No.: | 135531-86-1 |
| Chemical Name: | 3-(2-thiazolyl)-1H-indole |
| Synonyms: | |
| 分子量: | 200.26 |
| 分子式: | C₁₁H₈N₂S |
| SMILES: | C12=C(C=CC=C2)NC=C1C3=NC=CS3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Camalexin 是一种植物抗毒素，是从Camelina sativa和Arabidopsis（十字花科植物）中分离出来的，具有抗菌，抗真菌，抗增殖和抗癌活性。Camalexin 可诱导活性氧 (ROS) 的产生。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ahuja, I., Kissen, R., and Bones, A.M.Phytoalexins in defense against pathogensTrends Plant Sci.17(2),73-90(2012)
Mezencev, R., Updegrove, T., Kutschy, P., et al.Camalexin induces apoptosis in T-leukemia Jurkat cells by increased concentration of reactive oxygen species and activation of caspase-8 and caspase-9J. Nat. Med.65(3-4),488-499(2011)
Pilatova, M., Ivanova, L., Kutschy, P., et al.In vitro toxicity of camalexin derivatives in human cancer and non-cancer cellsToxicol. In Vitro27(2),939-944(2013)
Smith, B.A., Neal, C.L., Chetram, M., et al.The phytoalexin camalexin mediates cytotoxicity towards aggressive prostate cancer cells via reactive oxygen speciesJ. Nat. Med.67(3),607-618(2013)
Smith, B., Randle, D., Mezencev, R., et al.Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin DMolecules19(4),3988-4005(2014)
Festa, C., Renga, B., D'Amore, C., et al.Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligandsJ. Med. Chem.57(20),8477-8495(2014)
