Zidebactam
Cat. No.：YN250304
CAS No. ：1436861-97-0
| 产品名称: | Zidebactam |
| CAS No.: | 1436861-97-0 |
| Chemical Name: | (1R,2S,5R)-7-oxo-6-(sulfooxy)-2-[2-[(3R)-3-piperidinylcarbonyl]hydrazide], 1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid |
| Synonyms: | WCK-5107 |
| 分子量: | 391.40 |
| 分子式: | C₁₃H₂₁N₅O₇S |
| SMILES: | O=C([C@@H]1CCCNC1)NNC([C@@H]2CC[C@@H]3C[N@]2C(N3OS(=O)(O)=O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zidebactam (WCK-5107) 是一种有效的β-内酰胺酶抑制剂。Zidebactam 也是一种青霉素结合蛋白 2(PBP2) 抑制剂，其IC50为 0.26 μg/ml。 |
| IC50和靶点: | |
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Moya, B., Barcelo, I.M., Bhagwat, S., et al.WCK 5107 (zidebactam) and WCK 5153 are novel inhibitors of PBP2 showing potent "β-lactam enhancer" activity against Pseudomonas aeruginosa, including multidrug-resistant metallo-β-lactamase-producing high-risk clonesAntimicrob. Agents Chemother.61(6),e02529-02516(2017)
Sader, H.S., Rhomberg, P.R., Flamm, R.K., et al.WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamasesJ. Antimicrob. Chemother.72(6),1696-1703(2017)
Moya, B., Barcelo, I.M., Cabot, G., et al.In vitro and in vivo activities of β-lactams in combination with the novel β-lactam enhancers zidebactam and WCK 5153 against multidrug-resistant metallo-β-lactamase-producing Klebsiella pneumoniaeAntimicrob. Agents Chemother.63(5),e00128-00119(2019)
