NITD-916
Cat. No.：YN250327
| 产品名称: | NITD-916 |
| CAS No.: | 1614262-83-7 |
| Chemical Name: | 6-[(4,4-Dimethylcyclohexyl)methyl]-4-hydroxy-3-phenyl-2(1H)-pyridinone; 6-((4,4-Dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one |
| Synonyms: | NITD916 |
| 分子量: | 311.42 |
| 分子式: | C₂₀H₂₅NO₂ |
| SMILES: | O=C1C(C2=CC=CC=C2)=C(O)C=C(CC3CCC(C)(C)CC3)N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NITD-916 是一种 4-羟基-2-吡啶酮衍生物，是一种具有口服活性且高度亲脂性的分枝杆菌烯酰还原酶InhA抑制剂，IC50为 570 nM。NITD-916 与InhA和 NADH 形成三元复合物，以阻止进入脂肪酰基底物结合袋。NITD-916 具有有效的抗结核作用。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Ng, P. S., et al.: Eur. J. Med. Chem., 106, 144 (2015)
