Radezolid
Cat. No.：YN250597
| 产品名称: | Radezolid |
| CAS No.: | 869884-78-6 |
| Chemical Name: | N-[[(5S)-3-[2-fluoro-4′-[[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1′-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]-acetamide |
| Synonyms: | 雷得唑来; RX-1741 |
| 分子量: | 438.45 |
| 分子式: | C₂₂H₂₃FN₆O₃ |
| SMILES: | CC(NC[C@H]1CN(C2=CC=C(C3=CC=C(CNCC4=CN=NN4)C=C3)C(F)=C2)C(O1)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Radezolid (RX-1741) 是一种噁唑烷酮类抗生素。Radezolid 对葡萄球菌，衣原体和军团菌具有活性，对 Linezolid 耐药菌株也具有活性。 |
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Lawrence, L., Danese, P., DeVito, J., et al.In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogensAntimicrob. Agents Chemother.52(5),1653-1662(2008)
LeMaire, S., Kosowska-Shick, K., Appelbaum, P.C., et al.Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: Studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophilaAntimicrob. Agents Chemother.54(6),2549-2559(2010)
Skripkin, E., McConnell, T.S., DeVito, J., et al.Rx-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistanceAntimicrob. Agents Chemother.52(10),3550-3557(2008)
Zhou, J., Bhattacharjee, A., Chen, S., et al.Design at the atomic level: Design of biaryloxazolidinones as potent orally active antibioticsBioorg. Med. Chem. Lett.18(23),6175-6178(2008)
