Tedizolid phosphate
Cat. No.：YN250605
CAS No. ：856867-55-5
| 产品名称: | Tedizolid phosphate |
| CAS No.: | 856867-55-5 |
| Chemical Name: | (5R)-3-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-[(phosphonooxy)methyl]-2-oxazolidinone |
| Synonyms: | 磷酸特地唑胺; TR-701FA |
| 分子量: | 450.32 |
| 分子式: | C₁₇H₁₆FN₆O₆P |
| SMILES: | O=C1O[C@@H](COP(O)(O)=O)CN1C2=CC=C(C3=CC=C(C4=NN(C)N=N4)N=C3)C(F)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tedizolid phosphate (TR-701FA) 是MAO-A和MAO-B抑制剂，具有抗革兰氏阳性菌的活性。 |
| IC50和靶点: | |
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Ong, V., Flanagan, S., Fang, E., et al.Absorption, distribution, metabolism, and excretion of the novel antibacterial prodrug tedizolid phosphateDrug Metab. Dispos.42(8),1275-1284(2014)
Chan, L.C., Basuino, L., Dip, E.C., et al.Comparative efficacies of tedizolid phosphate, vancomycin, and daptomycin in a rabbit model of methicillin-resistant Staphylococcus aureus endocarditisAntimicrob. Agents Chemother.59(6),3252-3256(2015)
Bayer, A.S., Abdelhady, W., Li, L., et al.Comparative efficacies of tedizolid phosphate, linezolid, and vancomycin in a murine model of subcutaneous catheter-related biofilm infection due to methicillin-susceptible and -sesistant Staphylococcus aureusAntimicrob. Agents Chemother.60(8),5092-5096(2016)
Le, V.T.M., Le, H.N., Pinheiro, M.G., et al.Effects of tedizolid phosphate on survival outcomes and suppression of production of staphylococcal toxins in a rabbit model of methicillin-resistant Staphylococcus aureus necrotizing pneumoniaAntimicrob. Agents Chemother.61(4),e02734-02716(2017)
