1-Deoxynojirimycin hydrochloride
Cat. No.：YN250606
| 产品名称: | 1-Deoxynojirimycin hydrochloride |
| CAS No.: | 73285-50-4 |
| Chemical Name: | 2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, monohydrochloride |
| Synonyms: | Duvoglustat hydrochloride |
| 分子量: | 199.63 |
| 分子式: | C₆H₁₄ClNO₄ |
| SMILES: | O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) 是一种口服有效的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂。1-Deoxynojirimycin hydrochloride 抑制餐后血糖，预防糖尿病。1-Deoxynojirimycin hydrochloride 具有降血糖、减肥和抗病毒的作用。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Gao, K., Zheng, C., Wang, T., et al.1-Deoxynojirimycin: Occurrence, extraction, chemistry, oral pharmacokinetics, biological activities and in silico target fishingMolecules21(11),1600(2016)
Ahuja-Casarín, A.I., Merino-Montiel, P., Vega-Baez, J.L., et al.Tuning the activity of iminosugars: Novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitorsJ. Enzyme Inhib. Med. Chem.36(1),138-146(2021)
Codelli, J.A., Baskin, J.M., Agard, N.J., et al.Second-generation difluorinated cyclooctynes for copper-free click chemistryJ. Am. Chem. Soc.130(34),11486-11493(2008)
Papandréou, M.-J., Barbouche, R., Guieu, R., et al.The α-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding stepMol. Pharmacol.61(1),186-193(2002)
Wang, R.-J., Yang, C.-H., and Hu, M.-L.1-Deoxynojirimycin inhibits metastasis of B16F10 melanoma cells by attenuating the activity and expression of matrix metalloproteinases-2 and -9 and altering cell surface glycosylationJ. Agric. Food Chem.58(16),8988-8993(2010)
Liu, Q., Li, X., Li, C., et al.1-Deoxynojirimycin alleviates insulin resistance via activation of insulin signaling PI3K/AKT pathway in skeletal muscle of db/db miceMolecules20(12),21700-21714(2015)
