Epothilone D
Cat. No.：YN250628
CAS No. ：189453-10-9
| 产品名称: | Epothilone D |
| CAS No.: | 189453-10-9 |
| Chemical Name: | (4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-oxacyclohexadec-13-ene-2,6-dione |
| Synonyms: | KOS 862 |
| 分子量: | 491.68 |
| 分子式: | C₂₇H₄₁NO₅S |
| SMILES: | O=C(O[C@@H](C/C=C(CCC[C@@H]([C@@H]([C@H](C1=O)C)O)C)/C)/C(C)=C/C2=CSC(C)=N2)C[C@@H](C1(C)C)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Epothilone D (KOS 862) 是有效的微管稳定剂。 |
| IC50和靶点: | |
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Bollag, D.M., McQueney, P.A., Zhu, J., et al.Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of actionCancer Res.55(11),2325-2333(1995)
Goodin, S., Kane, M.P., and Rubin, E.H.Epothilones: Mechanism of action and biologic activityJ. Clin. Oncol.22(10),2015-2025(2011)
Cheng, K.L., Bradley, T., and Budman, D.R.Novel microtubule-targeting agents - the epothilonesBiologics2(4),789-811(2008)
Cartelli, D., Casagrande, F., Busceti, C.L., et al.Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotectiveSci. Rep.3,(2013)
Brunden, K.R., Zhang, B., Carroll, J., et al.Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathyJ. Neurosci.30(41),13861-13866(2010)
Lou, K., Yao, Y., Hoye, A.T., et al.Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathiesJ. Med. Chem.57(14),6116-6127(2014)
