CHIR-090
Cat. No.：YN250640
CAS No. ：728865-23-4
| 产品名称: | CHIR-090 |
| CAS No.: | 728865-23-4 |
| Chemical Name: | N-[(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[2-[4-(4-morpholinylmethyl)phenyl]ethynyl]-benzamide |
| Synonyms: | CHIR090 |
| 分子量: | 437.49 |
| 分子式: | C₂₄H₂₇N₃O₅ |
| SMILES: | O=C(N[C@@H]([C@@H](C)O)C(NO)=O)C(C=C1)=CC=C1C#CC2=CC=C(CN3CCOCC3)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CHIR-090是一种有效，缓慢，亲和力强的LpxC脱乙酰酶抑制剂。它与E. coliLpxC结合的Ki值为 4.0 nM。 |
| IC50和靶点: | |
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McClerren, A.L., Endsley, S., Bowman, J.L., et al.A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacinBiochemistry44(50),16574-16583(2005)
Barb, A.W., McClerren, A.L., Snehelatha, K., et al.Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coliBiochemistry46(12),3793-3802(2007)
Bodewits, K., Raetz, C.R., Govan, J.R., et al.Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complexAntimicrob. Agents Chemother.54(8),3531-3533(2010)
