Relebactam
Cat. No.：YN250679
CAS No. ：1174018-99-5
| 产品名称: | Relebactam |
| CAS No.: | 1174018-99-5 |
| Chemical Name: | mono[(1R,2S,5R)-7-oxo-2-[(4-piperidinylamino)carbonyl]-1,6-diazabicyclo[3.2.1]oct-6-yl] ester, sulfuric acid |
| Synonyms: | MK-7655 |
| 分子量: | 348.38 |
| 分子式: | C₁₂H₂₀N₄O₆S |
| SMILES: | O=S(ON1[C@]2([H])CC[C@@H](C(NC3CCNCC3)=O)[N@@](C2)C1=O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Relebactam是一种二氮杂双环辛烷抑制剂，具有广谱抗β内酰胺酶活性，包括A类（超广谱β内酰胺酶和KPC）和C类（AmpC酶）。 |
| IC50和靶点: | |
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Blizzard, T.A., Chen, H., Kim, S., et al.Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®Bioorg. Med. Chem. Lett24(3),780-785(2014)
Lob, S.H., Hackel, M.A., Kazmierczak, K.M., et al.In Vitro activity of imipenem-relebactam against Gram-negative ESKAPE pathogens Isolated by clinical laboratories in the United States in 2015 (results from the SMART global surveillance program)Antimicrob. Agents Chemother.61(6),e02209-02216(2017)
Mavridou, E., Melchers, R.J.B., van Mil, A.C.H.A.M., et al.Pharmacodynamics of imipenem in combination with β-lactamase inhibitor MK7655 in a murine thigh modelAntimicrob. Agents Chemother.59(2),790-795(2015)
