Rolipram
Cat. No.：YN250684
CAS No. ：61413-54-5
| 产品名称: | Rolipram |
| CAS No.: | 61413-54-5 |
| Chemical Name: | 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |
| Synonyms: | (R,S) |
| 分子量: | 275.34 |
| 分子式: | C₁₆H₂₁NO₃ |
| SMILES: | O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rolipram 是一种选择性的磷酸二酯酶PDE4抑制剂，抑制 PDE4A，PDE4B 和 PDE4D，的IC50分别为 3 nM，130 nM 和 240 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Tenor, H., Hatzelmann, A., Church, M.K., et al.Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjectsBr. J. Pharmacol.118,1727-1735(1996)
Souness, J.E., Griffin, M., Maslen, C., et al.Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformerBr. J. Pharmacol.118,649-658(1996)
Sasaki, T., Kitagawa, K., Omura-Matsuoka, E., et al.The phosphodiesterase inhibitor rolipram promotes survival of newborn hippocampal neurons after ischemiaStroke38,1597-1605(2007)
Kanes, S.J., Tokarczyk, J., Siegel, S.J., et al.Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activityNeuroscience144,239-246(2007)
Yao, W., Tian, X.Y., Chen, J., et al.Rolipram, a phosphodiesterase 4 inhibitor, prevented cancellous and cortical bone loss by inhibiting endosteal bone resorption and maintaining the elevated periosteal bone formation in adult ovariectomized ratsJ. Musculoskelet. Neuronal. Interact.7(2),119-130(2007)
