AFN-1252
Cat. No.：YN250686
CAS No. ：620175-39-5
| 产品名称: | AFN-1252 |
| CAS No.: | 620175-39-5 |
| Chemical Name: | N-methyl-N-[(3-methyl-2E-benzofuranyl)methyl]-3-(5,6,7,8-tetrahydro-7-oxo-1,8-naphthyridin-3-yl)-2-propenamide |
| Synonyms: | API-1252; Debio 1452 |
| 分子量: | 375.42 |
| 分子式: | C₂₂H₂₁N₃O₃ |
| SMILES: | O=C(N(C)CC1=C(C)C2=CC=CC=C2O1)/C=C/C(C=C3CC4)=CNC3=NC4=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AFN-1252(Debio 1452)是FabI高效抑制剂，能抑制金黄色葡萄球菌。 |
| IC50和靶点: | |
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Kaplan, N.O., Albert, M., Awrey, D.E., et al.Mode of action, in vitro activity, and in vivo efficacy of AFN-1252, a selective antistaphylococcal FabI inhibitorAntimicrob. Agents Chemother.56(11),5865-5874(2012)
Parsons, J.B., Frank, M.W., Subramanian, S., et al.Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitorsProc. Natl. Acad. Sci. USA108(37),15378-15383(2011)
Karlowsky, J.A., Kaplan, N.O., Hafkin, B., et al.AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activityAntimicrob. Agents Chemother.53(8),3544-3548(2009)
