Deferasirox
Cat. No.：YN250700
CAS No. ：201530-41-8
| 产品名称: | Deferasirox |
| CAS No.: | 201530-41-8 |
| Chemical Name: | 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-benzoic acid |
| Synonyms: | 地拉罗司; ICL 670 |
| 分子量: | 373.36 |
| 分子式: | C₂₁H₁₅N₃O₄ |
| SMILES: | O=C(O)C1=CC=C(N2N=C(C3=CC=CC=C3O)N=C2C4=CC=CC=C4O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Deferasirox (ICL 670) 是具有口活性的，可用于铁离子过量的螯合剂。 |
| IC50和靶点: | |
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Heinz, U., Hegetschweiler, K., Acklin, P., et al.4‐[3,5‐bis(2‐hydroxyphenyl)‐1,2,4‐triazol‐1‐yl]‐ benzoic acid: A novel efficient and selective iron(III) complexing agentAngew. Chem. Int. Ed.38(17),2568-2570(1999)
Hershko, C., Konijn, A.M., Nick, H.P., et al.ICL670A: A new synthetic oral chelator: Evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in cultureBlood97(4),1115-1122(2001)
Lee, J.-C., Chiang, K.-C., Feng, T.-H., et al.The iron chelator, Dp44mT, effectively inhibits human oral squamous cell carcinoma cell growth in vitro and in vivoInt. J. Mol. Sci.17(9),pii: E1435(2016)
Shinoda, S., Kaino, S., Amano, S., et al.Deferasirox, an oral iron chelator, with gemcitabine synergistically inhibits pancreatic cancer cell growth in vitro and in vivoOncotarget9(47),28434-28444(2018)
