Terbinafine hydrochloride
Cat. No.：YN250707
| 产品名称: | Terbinafine hydrochloride |
| CAS No.: | 78628-80-5 |
| Chemical Name: | N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine, monohydrochloride |
| Synonyms: | 盐酸特比萘芬; TDT 067 hydrochloride |
| 分子量: | 327.89 |
| 分子式: | C₂₁H₂₆ClN |
| SMILES: | CN(C/C([H])=C([H])/C#CC(C)(C)C)CC1=CC=CC2=CC=CC=C21.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Terbinafine hydrochloride (TDT 067hydrochloride) 是具有抗真菌感染活性的化合物。它是念珠菌属的角鲨烯环氧化酶有效的非竞争性抑制剂，Ki值为 30 nM。Terbinafine hydrochloride 还对某些革兰氏阳性和革兰氏阴性细菌具有抗菌活性。 |
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Petranyi, G., Meingassner, J.G., and Mieth, H.Antifungal activity of the allylamine derivative terbinafine in vitroAntimicrob. Agents Chemother.31(9),1365-1368(1987)
Ryder, N.S., and Dupont, M.C.Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymesBiochem. J.230(3),765-770(1985)
Lee, W.S., Chen, R.J., Wang, Y.J., et al.In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrestInt. J. Cancer106(1),125-137(2003)
Ho, P.Y., Liang, Y.C., Ho, Y.S., et al.Inhibition of human vascular endothelial cells proliferation by terbinafineInt. J. Cancer111(1),51-59(2004)
