Mevastatin
Cat. No.：YN250710
| 产品名称: | Mevastatin |
| CAS No.: | 73573-88-3 |
| Chemical Name: | 2S-methyl-(1S,2,3,7S,8S,8aR)-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2-H-pyran-2-yl]ethyl]-1-naphthalenyl ester-butanoic acid |
| Synonyms: | 美伐他汀; Compactin; ML236B |
| 分子量: | 390.51 |
| 分子式: | C₂₃H₃₄O₅ |
| SMILES: | CC[C@H](C)C(O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mevastatin (Compactin) 是第一个属于他汀类的HMG-CoA还原酶抑制剂。Mevastatin 是一种降脂药，可诱导细胞凋亡，将癌细胞阻滞在 G0/G1期。Mevastatin 还可以增加内皮型一氧化氮合酶 (eNOS) 的 mRNA 和蛋白质水平。Mevastatin 具有抗肿瘤活性，并可用于心血管疾病的研究。 |
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Endo, A., Kuroda, M., and Tanzawa, K.Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activityFEBS Lett.72(2),323-326(1976)
Fears, R., Richards, D.H., and Ferres, H.The effect of compactin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity, on cholesterogenesis and serum cholesterol levels in rats and chicksAtherosclerosis.35(4),439-449(1980)
Ahn, K.S., Sethi, G., and Aggarwal, B.B.Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathwayBiochem. Pharmacol.75(4),907-913(2008)
Conlon, M., Poltorack, C.D., Forcina, G.C., et al.A compendium of kinetic modulatory profiles identifies ferroptosis regulatorsNat. Chem. Biol.,(2021)
Endo, A.The discovery and development of HMG-CoA reductase inhibitorsJ. Lipid Res.33(11),1569-1582(1992)
