Fidaxomicin
Cat. No.：YN250757
CAS No. ：873857-62-6
| 产品名称: | Fidaxomicin |
| CAS No.: | 873857-62-6 |
| Chemical Name: | (3E,5E,8S,9E,11S,12R,13E,15E,18S)-3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyet |
| Synonyms: | OPT-80; PAR-101 |
| 分子量: | 1058.04 |
| 分子式: | C₅₂H₇₄Cl₂O₁₈ |
| SMILES: | O=C(C(C(O)=C(Cl)C(O)=C1Cl)=C1CC)O[C@H]([C@H](O[C@H]2OC/C(C(O[C@](C/C=C3C)([H])[C@H](O)C)=O)=C\C=C\C[C@@H](/C(C)=C\[C@H](CC)[C@@H](O[C@@](OC(C)(C)[C@@H](OC(C(C)C)=O)[C@@H]4O)([H])[C@H]4O)\C(C)=C/3)O)C)[C@@H]([C@@H]2OC)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fidaxomicin (OPT-80) 是一种大环RNA 聚合酶抑制剂，具有窄谱活性。 Fidaxomicin 选择性地根除致病性艰难梭菌 (Clostridium difficile)，对构成正常健康肠道菌群的多种细菌的破坏程度最小。 |
| IC50和靶点: | |
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Srivastava, A., Talaue, M., Liu, S., et al.New target for inhibition of bacterial RNA polymerase: "Switch region"Curr. Opin. Microbiol.14(5),532-543(2011)
Louie, T.J., Emery, J., Krulicki, W., et al.OPT-80 eliminates Clostridium difficile and is sparing of Bacteroides species during treatment of C. difficile infectionAntimicrob. Agents Chemother.53(1),261-263(2009)
Louie, T.J., Miller, M.A., Mullane, K.M., et al.Fidaxomicin versus vancomycin for Clostridium difficile infectionN. Engl. J. Med.364(5),422-431(2011)
