Solithromycin
Cat. No.：YN250765
CAS No. ：760981-83-7
| 产品名称: | Solithromycin |
| CAS No.: | 760981-83-7 |
| Chemical Name: | (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole |
| Synonyms: | 索利霉素; CEM-101; OP-1068 |
| 分子量: | 845.01 |
| 分子式: | C₄₃H₆₅FN₆O₁₀ |
| SMILES: | C[C@]([C@H](OC([C@@](F)(C([C@H](C)[C@H]1O[C@@](O[C@H](C)C[C@@H]2N(C)C)([H])[C@@H]2O)=O)C)=O)CC)(O3)[C@]([C@H](C([C@@H](C[C@@]1(C)OC)C)=O)C)([H])N(CCCCN4C=C(C5=CC(N)=CC=C5)N=N4)C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Solithromycin (CEM-101) 是一种口服可生物利用的，特别有效的抗菌剂，对肺炎链球菌，金黄色葡萄球菌和流感嗜血杆菌的生长活力，蛋白质合成和生长速率的IC50值分别为 7.5 ng/mL, 40 ng/mL 和 125 ng/mL。Solithromycin 可与核糖体的大 50S 亚基结合并抑制蛋白质生物合成。 |
| IC50和靶点: | |
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Roblin, P.M., Kohlhoff, S.A., Parker, C., et al.In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniaeAntimicrob. Agents Chemother.54(3),1358-1359(2010)
Wittlin, S., Ekland, E.H., Craft, J.C., et al.In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium speciesAntimicrob. Agents Chemother.56(2),703-707(2012)
