Framycetin
Cat. No.：YN250774
CAS No. ：119-04-0
| 产品名称: | Framycetin |
| CAS No.: | 119-04-0 |
| Chemical Name: | Dekamycin II; O-2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine; O-2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-α-D-gluc |
| Synonyms: | 新霉素B; Neomycin B; Fradiomycin B |
| 分子量: | 614.64 |
| 分子式: | C₂₃H₄₆N₆O₁₃ |
| SMILES: | N[C@@H](C[C@H]1N)[C@@]([C@@H]([C@H]1O)O[C@@](O[C@H](CO)[C@H]2O[C@@]([C@@H]([C@@H](O)[C@@H]3O)N)([H])O[C@H]3CN)([H])[C@@H]2O)([H])O[C@H]([C@@H]([C@@H](O)[C@@H]4O)N)O[C@@H]4CN |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Framycetin (Neomycin B) 是一种氨基糖苷类抗生素，是一种有效的RNase P裂解活性抑制剂，Ki为 35 μM。Framycetin 竞争 RNase P RNA 中特定的二价金属离子结合位点。Framycetin 抑制锤头状核酶 (hammerhead ribozyme)，Ki值为 13.5 μM。Framycetin 是 5″-azido neomycin B 前体，与 miR-525 中的 Drosha 位点结合，可用于肝性脑病和肠致病性大肠杆菌感染。 |
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| Solvent & Solubility: |
Umezawa, S., et al.: Bull. Chem. Soc. Jpm., 53, 3259 (1980)
The Journal of antibiotics, NO. 2. 189 (1977)
