Zoliflodacin
Cat. No.：YN250777
CAS No. ：1620458-09-4
| 产品名称: | Zoliflodacin |
| CAS No.: | 1620458-09-4 |
| Chemical Name: | (2R,4S,4aS)-11-fluoro-1,2,4,4a-tetrahydro-2,4-dimethyl-8-[(4S)-4-methyl-2-oxo-3-oxazolidinyl]-Spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5(6H),5′(2′H)-pyrimidine]-2′,4′,6′(1′H,3′H)-trione |
| Synonyms: | ETX0914; AZD0914 |
| 分子量: | 487.44 |
| 分子式: | C₂₂H₂₂FN₅O₇ |
| SMILES: | O=C(NC(C12[C@]([C@H](C)O[C@H](C)C3)([H])N3C4=C(C=C5C(ON=C5N6C(OC[C@@H]6C)=O)=C4F)C2)=O)NC1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zoliflodacin (ETX0914;AZD0914) 是一种新型的螺旋嘧啶三酮，细菌DNA促旋酶/拓扑异构酶抑制剂。Zoliflodacin 对革兰氏阳性和阴性生物具有有效的体外抗菌活性，对金黄色葡萄球菌的b>MIC90值为0.25 μg/mL。 |
| IC50和靶点: | |
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Jacobsson, S., Golparian, D., Alm, R.A., et al.High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug-resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrheaAntimicrob. Agents Chemother.58(9),5585-5588(2014)
Biedenbach, D.J., Huband, M.D., Hackel, M., et al.In vitro activity of AZD0914, a novel bacterial DNA gyrase/topoisomerase IV inhibitor, against clinically relevant Gram-positive and fastidious Gram-negative pathogensAntimicrob. Agents Chemother.59(10),6053-6063(2015)
Kohlhoff, S.A., Huband, M.D., and Hammerschlag, M.R.In vitro activity of AZD0914, a novel DNA gyrase inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniaeAntimicrob. Agents Chemother.58(12),7595-7596(2014)
