Aeroplysinin 1
Cat. No.：YN250819
CAS No. ：28656-91-9
| 产品名称: | Aeroplysinin 1 |
| CAS No.: | 28656-91-9 |
| Chemical Name: | (1S,6R)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonitrile |
| Synonyms: | (+)-Aeroplysinin-1 |
| 分子量: | 338.98 |
| 分子式: | C₉H₉Br₂NO₃ |
| SMILES: | N#CC[C@]1(O)C=C(Br)C(OC)=C(Br)[C@@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aeroplysinin 1 ((+)-Aeroplysinin-1)，从海洋海绵中分离出的次生代谢产物，对革兰氏阳性细菌 (bacteria) 显示出有效的抗生素作用，并具有针对HIV-1的抗病毒活性 (IC50=14.6 μM)。Aeroplysinin 1 具有抗炎，抗血管生成和抗肿瘤活性。Aeroplysinin 1诱导内皮细胞凋亡 (apoptosis)。 |
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Fattorusso, E., Minale, L., and Sodano, G.Aeroplysinin-1, an antibacterial bromo-compound from the sponge Verongia aerophobaJ. Chem. Soc. Perkin 11,16-18(1972)
Kreuter, M.H., Leake, R.E., Müller-Klieser, W., et al.Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1Comp. Biochem. Physiol. B97(1),151-158(1990)
Rodríguez-Nieto, S., González-Iriarte, M., Carmona, R., et al.Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine spongeFASEB J.16(2),261-263(2002)
García-Vilas, J.A., Martínez-Poveda, B., Quesada, A.R., et al.Aeroplysinin-1, a sponge-derived multi-targeted bioactive marine drugMar. Drugs14(1),(2015)
