Sandramycin
Cat. No.：YN250820
| 产品名称: | Sandramycin |
| CAS No.: | 100940-65-6 |
| Chemical Name: | N-[(3-hydroxy-2-quinolinyl)carbonyl]-D-seryl-(2S)-2-piperidinecarbonylglycyl-N-methylglycyl-N-methyl-L-valine, bimol. (5→1'3),(5'→13)-dilactone |
| Synonyms: | 山卓霉素 |
| 分子量: | 1221.32 |
| 分子式: | C₆₀H₇₆N₁₂O₁₆ |
| SMILES: | CC(C)[C@@H](C(OC[C@@H](NC(C1=C(O)C=C(C=CC=C2)C2=N1)=O)C3=O)=O)N(C)C(CN(C)C(CNC([C@@H]4CCCCN4C([C@@H](COC([C@H](C(C)C)N(C)C(CN(C)C(CNC([C@H]5N3CCCC5)=O)=O)=O)=O)NC(C6=C(O)C=C(C=CC=C7)C7=N6)=O)=O)=O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sandramycin 是一种从Nocardioides sp的培养液中分离出来的一种环状十肽抗菌素。Sandramycin 也可以有效地结合 DNA，并且是一种ADC的毒素分子。Sandramycin 对革兰氏阳性细菌 (Gram-positive bacteria) 具有活性，并具有有效的抗肿瘤活性。 |
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Matson, J.A., and Bush, J.A.Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. production, isolation, characterization and biological propertiesJ. Antibiot. (Tokyo)42(12),1763-1767(1989)
Boger, D.L., and Saionz, K.W.DNA binding properties of key sandramycin analogues: systematic examination of the intercalation chromophoreBioorg. Med. Chem.7(2),(1999)
