Cilastatin
Cat. No.：YN250876
CAS No. ：82009-34-5
| 产品名称: | Cilastatin |
| CAS No.: | 82009-34-5 |
| Chemical Name: | (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid |
| Synonyms: | 西司他丁; MK0791 |
| 分子量: | 358.45 |
| 分子式: | C₁₆H₂₆N₂O₅S |
| SMILES: | O=C(O)/C(NC([C@@H]1C(C)(C)C1)=O)=C/CCCCSC[C@H](N)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cilastatin (MK0791) 是一种可逆的竞争性的肾脏脱氢肽酶 I (renal dehydropeptidase I) 抑制剂，IC50为 0.1 μM。Cilastatin 抑制细菌金属叶内酰胺酶CphA的IC50为 178 μM。Cilastatin 可用作抗菌辅助剂。 |
| IC50和靶点: | |
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Campbell, B.J., Forrester, L.J., Zahler, W.L., et al.Beta-lactamase activity of purified and partially characterized human renal dipeptidaseJ. Biol. Chem.259(23),14586-14590(1984)
Kahan, F.M., Kropp, H., Sundelof, J.G., et al.Thienamycin: Development of imipenen-cilastatinJ. Antimicrob. Chemother.12(Suppl. D),1-35(1983)
Keynan, S., Hooper, N.M., Felici, A., et al.The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-β-lactamase enzyme CphAAntimicrob. Agents Chemother.39(7),1629-1631(1995)
Humanes, B., Jado, J.C., Camaño, S., et al.Protective effects of cilastatin against vancomycin-induced nephrotoxicityBiomed Res. Int.,704382(2015)
Petersen, P.J., Jacobus, N.V., Weiss, W.J., et al.In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase IAntimicrob. Agents Chemother.35(1),203-207(1991)
