Trovafloxacin
Cat. No.：YN250878
| 产品名称: | Trovafloxacin |
| CAS No.: | 147059-72-1 |
| Chemical Name: | 7-((1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid; Turvel; 3-Azabicyclo[3.1.0]hexane, 1,8-naphthyridine-3-carboxylic acid derivative; |
| Synonyms: | 曲伐沙星 |
| 分子量: | 416.35 |
| 分子式: | C₂₀H₁₅F₃N₄O₃ |
| SMILES: | O=C(C1=CN(C2=CC=C(F)C=C2F)C3=NC(N4C[C@@]5([H])[C@H](N)[C@@]5([H])C4)=C(F)C=C3C1=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Trovafloxacin 是一种广谱喹诺酮类抗生素，对革兰氏阳性，革兰氏阴性和厌氧菌具有有效的活性。Trovafloxacin 可阻断 DNA 促旋酶 (DNA gyrase) 和拓扑异构酶 IV (topoisomerase IV) 的活性。Trovafloxacin 也是一种有效的，选择性的，口服活性的Pannexin 1通道 (PANX1) 抑制剂，对PANX1内向电流的IC50为 4 μM。Trovafloxacin 不抑制 connexin 43 gap junction 或 PANX2。Tr |
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| Solvent & Solubility: |
Garg, C., et al.: J. Neuroinflammation, 15, 42 (2018)
Angus, J. A., et al.: Eur. J. Pharmacol., 791, 179 (2016)
