Polymyxin B Sulfate
Cat. No.：YN250886
| 产品名称: | Polymyxin B Sulfate |
| CAS No.: | 1405-20-5 |
| Chemical Name: | N-(4-amino-1-((1-((4-amino-1-oxo-1-((6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-me |
| Synonyms: | 硫酸多粘菌素 B |
| 分子量: | 1287.53 (PolymyxinB2Sulfate) |
| 分子式: | C₅₅H₉₆N₁₆O₁₃.H₂SO₄ (Polymyxin B₂ Sulfate) |
| SMILES: | O=S(O)(O)=O.O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@]1([H])[C@H](O)C)=O)CCN)=O)([H])CCN)=O)CC(C)C)[C@H](NC([C@@H](NC([C@@](CCNC1=O)([H])NC([C@H](CCN)NC([C@H]([C@H](O)C)NC([C@H](CCN)NC(CCCCC(C)C)=O)=O)=O)=O)=O)CCN)=O)CC2=CC=CC=C2.O=C(N[C@H](C(N[C@@](C(N[C@H](C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Polymyxin B Sulfate是一个阳离子型表面活性剂抗生素剂，是polymyxins B1 和B2的混合物，能够提高细胞膜的渗透性。 |
| IC50和靶点: | |
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Falagas, M.E., and Kasiakou, S.K.Toxicity of polymyxins: A systematic review of the evidence from old and recent studiesCrit. Care10(1),(2006)
Hancock, R.E.W.Cationic peptides: Effectors in innate immunity and novel antimicrobialsLancet Infect. Dis.1(3),156-164(2001)
Tam, V.H., Cao, H., Ledesma, K.R., et al.In vitro potency of various polymyxin B componentsAntimicrob. Agents Chemother.55(9),4490-4491(2011)
Zavascki, A.P., Goldani, L.Z., Li, J., et al.Polymyxin B for the treatment of multidrug-resistant pathogens: A critical reviewJ. Antimicrob. Chemother.60(6),1206-1215(2007)
