Polymyxin B1
Cat. No.：YN250887
| 产品名称: | Polymyxin B1 |
| CAS No.: | 4135-11-9 |
| Chemical Name: | (S)-N-((S)-4-amino-1-(((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-h |
| Synonyms: | 硫酸多粘 B1 |
| 分子量: | 1203.48 |
| 分子式: | C₅₆H₉₈N₁₆O₁₃ |
| SMILES: | O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@]1([H])[C@H](O)C)=O)CCN)=O)([H])CCN)=O)CC(C)C)[C@H](NC([C@@H](NC([C@@](CCNC1=O)([H])NC([C@H](CCN)NC([C@H]([C@H](O)C)NC([C@H](CCN)NC(CCCC[C@@H](C)CC)=O)=O)=O)=O)=O)CCN)=O)CC2=CC=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Polymyxin B1 是一种有效的抗菌脂肽，衍生自多头芽孢杆菌。Polymyxin B1 是 Polymyxin B (HY-A0248) 的主要成分。Polymyxin B1 可以通过与细菌细胞膜的相互作用来诱导细菌细胞裂解。Polymyxin B1 可用于多重耐药性革兰氏阴性菌感染的研究。 |
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Falagas, M.E., and Kasiakou, S.K.Toxicity of polymyxins: A systematic review of the evidence from old and recent studiesCrit. Care10(1),(2006)
Hancock, R.E.W.Cationic peptides: Effectors in innate immunity and novel antimicrobialsLancet Infect. Dis.1(3),156-164(2001)
Tam, V.H., Cao, H., Ledesma, K.R., et al.In vitro potency of various polymyxin B componentsAntimicrob. Agents Chemother.55(9),4490-4491(2011)
