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Sulfapyridine

Cat. No.:YN250948

  • CAS No. :144-83-2

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    • 生物活性
    • 参考文献
    • 产品名称: Sulfapyridine
      CAS No.: 144-83-2
      Chemical Name: 4-amino-N-2-pyridinyl-benzenesulfonamide
      Synonyms:磺胺吡啶
      分子量:249.29
      分子式:C₁₁H₁₁N₃O₂S
      SMILES:O=S(C1=CC=C(N)C=C1)(NC2=NC=CC=C2)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Sulfapyridine 是 Sulfasalazine 的主要代谢产物,是一种磺酰胺类抗生素。Sulfapyridine 抑制重组P. carinii二氢蝶呤合成酶 (DHPS),IC50为 0.18 μM。Sulfapyridine 具有抗菌,抗炎和抗风湿作用。
      IC50和靶点:
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      In Vivo:
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    • Lorincz, A.L., and Pearson, R.W.Sulfapyridine and sulfone type drugs in dermatologyArch. Dermatol.85(1),42-56(1962)

      Couto, D., Ribeiro, D., Freitas, M., et al.Scavenging of reactive oxygen and nitrogen species by the prodrug sulfasalazine and its metabolites 5-aminosalicylic acid and sulfapyridineRedox Rep.15(6),259-267(2010)

      Andreasen, J.J., Andersen, L.P., and Hartzen, S.H.In vitro susceptibility of diarrhoea producing gram negative enteric bacteria to sulfasalazine, 5-aminosalicylic acid, sulfapyridine and four quinolones. Brief reportAPMIS96(6),568-570(1988)

      Wood, W.B., and Austrian, R.Studies on the antibacterial action of the sulfonamide drugs: II. The possible relation of drug activity to substances other than p-aminobenzoic acidJ. Exp. Med.75(4),383-394(1942)

      Hong, Y.-L., Hossler, P.A., Calhoun, D.H., et al.Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugsAntimicrob. Agents Chemother.39(8),1756-1763(1995)

      Kim, H.-M., An, N.-H., Yi, B.-H., et al.Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridineImmunopharmacol. Immunotoxicol.22(2),253-266(2000)

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