Enoxacin
Cat. No.：YN250971
| 产品名称: | Enoxacin |
| CAS No.: | 74011-58-8 |
| Chemical Name: | 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid |
| Synonyms: | 依诺沙星; AT 2266; CI 919 |
| 分子量: | 320.32 |
| 分子式: | C₁₅H₁₇FN₄O₃ |
| SMILES: | O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCNCC3)=N2)C1=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Enoxacin (AT 2266) 是一种氟喹诺酮，可以干扰DNA复制，抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。Enoxacin 有效抑制革兰氏阳性和阴性细菌。Enoxacin 是一种特异性的癌症生长抑制剂，可增强 TAR RNA 结合蛋白 2 (TRBP) 介导的 microRNA 加工。 |
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Clarke, A.M., Zemcov, S.J., and Campbell, M.E.In-vitro activity of pefloxacin compared to enoxacin, norfloxacin, gentamicin and new β-lactamsJ. Antimicrob. Chemother.15(1),39-44(1985)
Takei, M., Fukuda, H., Kishii, R., et al.Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibitionAntimicrob. Agents Chemother.45(12),3544-3547(2001)
Ozaki, M., Matsuda, M., Tomii, Y., et al.In vivo evaluation of NM441, a new thiazeto-quinoline derivativeAntimicrob. Agents Chemother.35(12),2496-2499(1991)
Luo, X., Liu, X., Tao, Q., et al.Enoxacin inhibits proliferation and invasion of human osteosarcoma cells and reduces bone tumour volume in a murine xenograft modelOncol. Lett.20(2),1400-1408(2020)
