Pyrazinamide
Cat. No.：YN250974
| 产品名称: | Pyrazinamide |
| CAS No.: | 98-96-4 |
| Chemical Name: | 2-pyrazinecarboxamide |
| Synonyms: | 吡嗪酰胺; Pyrazinecarboxamide; Pyrazinoic acid amide |
| 分子量: | 123.11 |
| 分子式: | C₅H₅N₃O |
| SMILES: | O=C(C1=NC=CN=C1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) 是一种有效的口服抗结核类抗生素 (antitubercular antibiotic)。Pyrazinamide 是一种前药，通过结核分枝杆菌pncA基因编码的 PZase/烟酰胺酶转化为活性吡嗪酸 (POA) 形式。 |
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Solotorovsky, M., Gregory, F.J., Ironson, E.J., et al.Pyrazinoic acid amide; An agent active against experimental murine tuberculosisProc. Soc. Exp. Biol. Med.79(4),563-565(1952)
Malone, L., Schurr, A., Lindh, H., et al.The effect of pyrazinamide (aldinamide) on experimental tuberculosis in miceAm. Rev. Tuberc.65(5),511-518(1952)
Chang, Y.T.Chemotherapy of murine leprosy. III. The effects of nicotinamide and pyrazinamide (aldinamide) on mouse leprosyInt. J. Lepr.22(3),331-346(1954)
Nguyen, Q.H., Contamin, L., Tran, T.T.H., et al.Molecular analysis of pyrazinamide resistance in Mycobacterium tuberculosis in Vietnam highlights the high rate of pyrazinamide resistance-associated mutations in clinical isolatesEmerg. Microbes Infect.6(10),e86(2017)
