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Sulbactam

Cat. No.:YN251007

  • CAS No. :68373-14-8

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    • 参考文献
    • 产品名称: Sulbactam
      CAS No.: 68373-14-8
      Chemical Name: (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 4,4-dioxide
      Synonyms:舒巴坦; CP45899
      分子量:233.24
      分子式:C₈H₁₁NO₅S
      SMILES:O=C([C@@H](C(C)(C)S([C@]1([H])C2)(=O)=O)N1C2=O)O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Sulbactam (CP45899) 是一种竞争性、不可逆的 β-内酰胺酶 (beta-lactamase) 抑制剂。Sulbactam 具有抗菌活性,抑制耐多药不动杆菌-鲍曼不动杆菌复合物。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Worthington, R.J., and Melander, C.Overcoming resistance to β-lactam antibioticsJ. Org. Chem.78(9),4207-4213(2013)

      Fair, R.J., and Tor, Y.Antibiotics and bacterial resistance in the 21st centuryPerspect. Medicin. Chem.6,25-64(2014)

      Bush, K.β-Lactamase inhibitors from laboratory to clinicClin. Microbiol. Rev.1(1),109-123(1988)

      Williams, J.D.β-Lactamase inhibition and in vitro activity of sulbactam and sulbactam/cefoperazoneClin. Infect. Dis.24(3),494-497(1997)

      Chaïbi, E.B., Sirot, D., Paul, G., et al.Inhibitor-resistant TEM β-lactamases: Phenotypic, genetic and biochemical characteristicsJ. Antimicrob. Chemother.43(4),447-458(1999)

      Drawz, S.M., and Bonomo, R.A.Three decades of β-lactamase inhibitorsClin. Microbiol. Rev.23(1),160-201(2010)

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