Sitafloxacin
Cat. No.：YN251027
CAS No. ：127254-12-0
| 产品名称: | Sitafloxacin |
| CAS No.: | 127254-12-0 |
| Chemical Name: | 7-[(7S)-7-amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
| Synonyms: | 西他沙星; DU6859a |
| 分子量: | 409.81 |
| 分子式: | C₁₉H₁₈ClF₂N₃O₃ |
| SMILES: | O=C(C1=CN([C@H]2[C@@H](F)C2)C3=C(C=C(F)C(N(C[C@H]4N)CC54CC5)=C3Cl)C1=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sitafloxacin (DU6859a) 是一种有效的口服氟喹诺酮类抗生素 (antibiotic)，体外活性可对抗广泛的革兰氏阳性和阴性细菌，包括厌氧菌，以及非典型病原体。Sitafloxacin 可用于呼吸道感染和尿路感染的研究。 |
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Nakane, T., Iyobe, S., Sato, K., et al.In vitro antibacterial activity of DU-6859a, a new fluoroquinoloneAntimicrob. Agents Chemother.39(12),2822-2826(1995)
Okumura, R., Hirata, T., Onodera, Y., et al.Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: Contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniaeJ. Antimicrob. Chemother.62(1),98-104(2008)
Onodera, Y., Tanaka, M., and Sato, K.Inhibitory activity of quinolones against DNA gyrase of Mycobacterium tuberculosisJ. Antimicrob. Chemother.47(4),447-450(2001)
Sano, C., Tatano, Y., Shimizu, T., et al.Comparative in vitro and in vivo antimicrobial activities of sitafloxacin, gatifloxacin and moxifloxacin against Mycobacterium aviumInt. J. Antimicrob. Agents37(4),296-301(2011)
