Trimethoprim
Cat. No.：YN251077
| 产品名称: | Trimethoprim |
| CAS No.: | 738-70-5 |
| Chemical Name: | 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine |
| Synonyms: | 甲氧苄啶 |
| 分子量: | 290.32 |
| 分子式: | C₁₄H₁₈N₄O₃ |
| SMILES: | NC1=NC=C(CC2=CC(OC)=C(OC)C(OC)=C2)C(N)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Trimethoprim 是一种抑菌抗生素，也是一种具有口服活性的二氢叶酸还原酶 (dihydrofolate reductase) 抑制剂。Trimethoprim 对多种革兰氏阳性和革兰氏阴性需氧细菌 (Gram-positive和Gram-negative aerobic bacteria) 具有活性。Trimethoprim 可用于尿路感染，志贺氏菌病和肺孢子菌肺炎的研究。 |
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Lam, T., Hilgers, M.T., Cunningham, M.L., et al.Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolinesJ. Med. Chem.57(3),651-668(2014)
Schweitzer, B.I., Dicker, A.P., and Bertino, J.R.Dihydrofolate reductase as a therapeutic targetFASEB J.4(8),2441-2452(1990)
