Fosfomycin tromethamine
Cat. No.：YN251106
| 产品名称: | Fosfomycin tromethamine |
| CAS No.: | 78964-85-9 |
| Chemical Name: | P-[(2R,3S)-3-methyl-2-oxiranyl]-phosphonic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol |
| Synonyms: | 磷霉素氨丁三醇; MK-0955 tromethamine |
| 分子量: | 259.19 |
| 分子式: | C₇H₁₈NO₇P |
| SMILES: | C[C@@H]1O[C@@H]1P(O)(O)=O.OCC(CO)(N)CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fosfomycin tromethamine (MK-0955 tromethamine) 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。Fosfomycin tromethamine 对多种细菌具有杀菌活性，这些细菌包括耐多药 (MDR)，广泛耐药 (XDR) 和耐全药 (PDR) 细菌。 |
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Mezzatesta, M.L., La Rosa, G., Maugeri, G., et al.In vitro activity of fosfomycin trometamol and other oral antibiotics against multi-drug-resistant uropathogensInt. J. Antimicrob. Agents49(6),763-766(2017)
Kahan, F.M., Kahan, J.S., Cassidy, P.J., et al.The mechanism of action of fosfomycin (phosphonomycin)Ann. N. Y. Acad. Sci.235(0),364-386(1974)
Santoro, A., Cappello, A.R., Madeo, M., et al.Interaction of fosfomycin with the glycerol 3-phosphate transporter of Escherichia coliBiochim. Biophys. Acta1810(12),1323-1329(2011)
