Paromomycin sulfate
Cat. No.：YN251181
| 产品名称: | Paromomycin sulfate |
| CAS No.: | 1263-89-4 |
| Chemical Name: | O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine, sulfate |
| Synonyms: | 硫酸巴龙霉素; Aminosidine sulfate |
| 分子量: | 713.71 |
| 分子式: | C₂₃H₄₇N₅O₁₈S |
| SMILES: | N[C@@H](C[C@H]1N)[C@@]([C@@H]([C@H]1O)O[C@@](O[C@H](CO)[C@H]2O[C@@]([C@@H]([C@@H](O)[C@@H]3O)N)([H])O[C@H]3CN)([H])[C@@H]2O)([H])O[C@H]([C@@H]([C@@H](O)[C@@H]4O)N)O[C@@H]4CO.O=S(O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Paromomycin (Aminosidine) sulfate 是一种的广谱氨基糖苷类抗生素 (antibiotic)，具有杀螨杀菌作用，是新霉素 (HY-B0470) 衍生物。Paromomycin sulfate 通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合，使 mRNA 的翻译提前终止，并抑制蛋白质合成。Paromomycin sulfate 可用于细菌和寄生虫感染的研究。 |
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Taniyama, H., Sawada, Y., and Tanaka, S.Antibiotics aminosidin. II. Some amino derivatives of aminosidin and their biological activityChem. Pharm. Bull. (Tokyo)21(3),609-615(1973)
Heidari-Kharaji, M., Taheri, T., Doroud, D., et al.Solid lipid nanoparticle loaded with paromomycin: In vivo efficacy against Leishmania tropica infection in BALB/c mice modelAppl. Microbiol. Biotechnol.100(16),7051-7060(2016)
Vicens, Q., and Westhof, E.Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A siteStructure9(8),647-658(2001)
