Mupirocin
Cat. No.：YN251183
| 产品名称: | Mupirocin |
| CAS No.: | 12650-69-0 |
| Chemical Name: | 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2S,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]oxiranyl]methyl]-3-methyl-L-talo-non-2E-enonic acid, 8-carboxyoctyl ester |
| Synonyms: | 莫匹罗星; BRL-4910A; Pseudomonic acid |
| 分子量: | 500.62 |
| 分子式: | C₂₆H₄₄O₉ |
| SMILES: | O[C@@H]1[C@@](CO[C@@H](C/C(C)=C/C(OCCCCCCCCC(O)=O)=O)[C@@H]1O)([H])C[C@H]2[C@@]([C@@H](C)[C@@H](O)C)([H])O2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mupirocin (BRL-4910A) 是从Pseudomonas fluorescens中分离得到的一种有口服活性的抗生素。Mupirocin (BRL-4910A) 通过可逆地抑制异亮氨酸转移RNA，从而抑制细菌蛋白和RNA的合成而发挥抗菌作用。 |
| IC50和靶点: | |
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Fuller, A.T., Mellows, G., Woolford, M., et al.Psuedomonic acid: An antibiotic produced by Pseudomonas fluorescensNature234(5329),416-417(1971)
Yang, N., Cui, H., Han, F., et al.Paeoniflorin inhibits human pancreatic cancer cell apoptosis via suppression of MMP-9 and ERK signalingOncol. Lett.12(2),1471-1476(2016)
Mohammad, H., Cushman, M., and Seleem, M.N.Antibacterial evaluation of synthetic thiazole compounds in vitro and in vivo in a methicillin-resistant Staphylococcus aureus (MRSA) skin infection mouse modelPLoS One10(11),e0142321(2015)
Khoshnood, S., Heidary, M., Asadi, A., et al.A review on mechanism of action, resistance, synergism, and clinical implications of mupirocin against Staphylococcus aureusBiomed. Pharmacother.109,1809-1818(2019)
