Thiostrepton
Cat. No.：YN251193
| 产品名称: | Thiostrepton |
| CAS No.: | 1393-48-2 |
| Chemical Name: | N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,1 |
| Synonyms: | 硫链丝菌素 |
| 分子量: | 1664.89 |
| 分子式: | C₇₂H₈₅N₁₉O₁₈S₅ |
| SMILES: | O=C([C@@H](NC(C(NC([C@@H](NC(C(NC(C=C1)C2([H])O)[C@@H](C)CC)=O)C)=O)=C)=O)C)N[C@](C3=NC(C(NC(C(N/C(C4=N[C@]5([H])CS4)=C\C)=O)[C@H](O)C)=O)=CS3)(CCC(C6=NC(C(NC(C(NC(C(N)=O)=C)=O)=C)=O)=CS6)=N7)[C@@]7([H])C8=CSC([C@@]([C@H](OC(C9=CC([C@@H](O)C)=C1C2=N9)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thiostrepton 是一种抗生素，可选择性抑制FOXM1。FOXM1 与 YAP/TEAD 复合物结合。YAP/TEAD/FOXM1 复合物在控制细胞周期的基因调控区域结合可能会影响细胞增殖。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bhat, U.G., Halasi, M., and Gartel, A.L.Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cellsPLoS One4(5),e5592(2009)
Gartel, A.L.Thiazole antibiotics siomycin A and thiostrepton inhibit the transcriptional activity of FOXM1Front. Oncol.3,150(2013)
Gartel, A.L.Suppression of the oncogenic transcription factor FOXM1 by proteasome inhibitorsScientifica (Cairo)2014:596528,(2014)
