Sulfaphenazole
Cat. No.：YN251260
| 产品名称: | Sulfaphenazole |
| CAS No.: | 526-08-9 |
| Chemical Name: | 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-benzenesulfonamide |
| Synonyms: | 磺胺苯吡唑 |
| 分子量: | 314.36 |
| 分子式: | C₁₅H₁₄N₄O₂S |
| SMILES: | O=S(C1=CC=C(N)C=C1)(NC2=CC=NN2C3=CC=CC=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sulfaphenazole是CYP2C9的特异性抑制剂, 抑制CYP2C9介导的亚油酸动脉粥样硬化和促炎症效应 (增加AP-1的氧化应激和激活), 用作抗菌剂。 |
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Rettie, A.E., and Jones, J.P.Clinical and toxicological relevance of CYP2C9: Drug-drug interactions and pharmacogeneticsAnnu. Rev. Pharmacol. Toxicol.45,477-494(2005)
Mancy, A., Dijols, S., Poli, S., et al.Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: Molecular origin of the specific inhibitory effects of sulfaphenazole on CYP 2C9 and consequences for the substrate binding site topology of CYP 2C9Biochemistry35(50),16205-16212(1996)
Sai, Y., Dai, R., Yang, T.J., et al.Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450Xenobiotica30(4),327-343(2000)
Fleming, I., Michaelis, U.R., Bredenkötter, D., et al.Endothelium-derived hyperpolarizing factor synthase (cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteriesCirc. Res.88(1),44-51(2001)
