Thonzonium bromide
Cat. No.：YN251268
CAS No. ：553-08-2
| 产品名称: | Thonzonium bromide |
| CAS No.: | 553-08-2 |
| Chemical Name: | N-[2-[[(4-methoxyphenyl)methyl]-2-pyrimidinylamino]ethyl]-N,N-dimethyl-1-hexadecanaminium, monobromide |
| Synonyms: | 通佐溴胺 |
| 分子量: | 591.71 |
| 分子式: | C₃₂H₅₅BrN₄O |
| SMILES: | CCCCCCCCCCCCCCCC[N+](C)(CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=N2)C.[Br-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thonzonium bromide，一种结构上与 Farnesol (HY-Y0248A) 相似的抗菌剂，是一种单阳离子表面活性剂，在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收，并在体内阻止 LPS 诱导的骨丢失。Thonzonium bromide 以剂量依赖的方式抑制质子转运 (EC50=69 μM)。 |
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Zhu, X., Gao, J.J., Landao-Bassonga, E., et al.Thonzonium bromide inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivoBiochem. Pharmacol.104,118-130(2016)
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