Diaveridine
Cat. No.：YN251378
| 产品名称: | Diaveridine |
| CAS No.: | 5355-16-8 |
| Chemical Name: | 5-[(3,4-dimethoxyphenyl)methyl]-2,4-pyrimidinediamine |
| Synonyms: | 二氨藜芦啶; EGIS-5645 |
| 分子量: | 260.29 |
| 分子式: | C₁₃H₁₆N₄O₂ |
| SMILES: | NC1=NC=C(CC2=CC=C(OC)C(OC)=C2)C(N)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Diaveridine (EGIS-5645) 是二氢叶酸还原酶 (DHFR) 的抑制剂，对于野生型 DHFR 的Ki值为 11.5 nM，Diaveridine 也是一种抗菌剂。 |
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Sirichaiwat, C., Intraraudom, C., Kamchonwongpaisan, S., et al.Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: Their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparumJ. Med. Chem.47(2),345-354(2004)
Roth, B., Falco, E.A., Hitchings, G.H., et al.5-Benzyl-2,4-diaminopyrimidines as antibacterial agents. I. Synthesis and antibacterial activity in vitroJ. Med. Chem.5(6),1103-1123(1962)
Ryley, J.F., and Betts, M.J.Chemotherapy of chicken coccidiosisAdvances in Pharmacology11,221-293(1973)
Wang, J., Sun, F., Tang, S., et al.Acute, mutagenicity, teratogenicity and subchronic oral toxicity studies of diaveridine in rodentsEnviron. Toxicol. Pharmacol.40(2),660-670(2015)
