Sofalcone
Cat. No.：YN251411
CAS No. ：64506-49-6
| 产品名称: | Sofalcone |
| CAS No.: | 64506-49-6 |
| Chemical Name: | 2-[5-[(3-methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]-acetic acid |
| Synonyms: | 索法酮 |
| 分子量: | 450.52 |
| 分子式: | C₂₇H₃₀O₆ |
| SMILES: | O=C(O)COC1=CC(OC/C=C(C)/C)=CC=C1C(/C=C/C2=CC=C(OC/C=C(C)/C)C=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sofalcone 是一种抗胃溃疡剂，可以诱导血红素加氧酶-1 (HO-1) 在胃肠上皮中的表达。 |
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Kimura, M., Saziki, R., Arai, I., et al.Effect of 2'-carboxymethoxy-4, 4'-bis(3-methyl-2-butenyloxy) chalcone (sofalcone) on chronic gastric ulcers in ratsJpn. J. Pharmacol.35(4),389-396(1984)
Suwa, T., Nakazima, M., Shinozaki, A., et al.Cytoprotective effect of SU-88, an anti-ulcer agent, in the ratJpn. J. Pharmacol.35,47-53(1984)
Tanaka, H., Nakamura, S., Onda, K., et al.Sofalcone, an anti-ulcer chalcone derivative, suppresses inflammatory crosstalk between macrophages and adipocytes and adipocyte differentiation: Implication of heme-oxygenase-1 inductionBiochem. Biophys. Res. Commun.381(4),566-571(2009)
Isomoto, H., Furusu, H., Ohnita, K., et al.Sofalcone, a mucoprotective agent, increases the cure rate of Helicobacter pylori infection when combined with rabeprazole, amoxicillin and clarithromycinWorld J. Gastroenterol.11(11),1629-1633(2005)
Higuchi, K., Watanabe, T., Tanigawa, T., et al.Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Heliobacter pylori: A randomized controlled comparative trial with cimetidine, an H2-receptor antagonistJ. Gastroenterol. Hepatol.25,S155-S160(2010)
Shibuya, A., Onda, K., Kawahara, H., et al.Sofalcone, a gastric mucosa protective agent, increases vascular endothelial growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cellsBiochem. Biophys. Res. Commun.398(3),581-584(2010)
