Oridonin
Cat. No.：YN251429
CAS No. ：28957-04-2
| 产品名称: | Oridonin |
| CAS No.: | 28957-04-2 |
| Chemical Name: | 7,20-epoxy-1α,6β,7α,14R-tetrahydroxy-kaur-16-en-15-one |
| Synonyms: | 冬凌草甲素; NSC-250682; Isodonol |
| 分子量: | 364.43 |
| 分子式: | C₂₀H₂₈O₆ |
| SMILES: | O[C@@H]1[C@]2(CO3)[C@@]([C@H](O)[C@]3(O)[C@]45[C@@]2([H])CC[C@](C(C5=O)=C)([H])[C@@]4([H])O)([H])C(C)(C)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oridonin (NSC-250682) 是从Rabdosia rubescens中得到的二萜，为AKT抑制剂，对 AKT1 和 AKT2 的IC50值分别为 8.4 和 8.9 μM；Oridonin 具有抗肿瘤、抗菌、抗炎等功效。 |
| IC50和靶点: | [{name:"Akt1:8.4 μM (IC50)"},{name: "Akt2:8.9 μM (IC50)"}] |
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Song, M., Liu, X., Liu, K., et al.Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient-derived xenografts in vivoMol. Cancer. Ther.17(7),1540-1553(2018)
He, H., Jiang, H., Chen, Y., et al.Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activityNat. Commun.9(1),2550(2018)
