Saikosaponin A
Cat. No.：YN251456
CAS No. ：20736-09-8
| 产品名称: | Saikosaponin A |
| CAS No.: | 20736-09-8 |
| Chemical Name: | (3β,4α,16β)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside |
| Synonyms: | 柴胡皂苷 A |
| 分子量: | 780.98 |
| 分子式: | C₄₂H₆₈O₁₃ |
| SMILES: | OC[C@H]1O[C@](O[C@@H]2[C@@H](O)[C@@](O[C@@H]3[C@@](C)(CO)[C@@](CC[C@]4(C)[C@]5([H])C=C[C@@]6(OC7)[C@@]4(C)C[C@H](O)[C@]87[C@@]6([H])CC(C)(C)CC8)([H])[C@]5(C)CC3)([H])O[C@H](C)[C@@H]2O)([H])[C@H](O)[C@@H](O)[C@@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Saikosaponin A 是从银柴胡中的主要活性成分，可上调LXRα的表达，具有有效抗炎活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Xu, X.-H., Li, T., Fong, C.M., et al.Saponins from Chinese medicines as anticancer agentsMolecules21(10),pii:E1326(2016)
Han, N.R., Kim, H.M., and Jeong, H.J.Inactivation of cystein-aspartic acid protease (caspase)-1 by saikosaponin A.Biol. Pharm. Bull.34(6),817-823(2011)
Xie, W., Yu, Y.H., Du, Y.P., et al.Saikosaponin a enhances transient inactivating potassium current in rat hippocampal CA1 neuronsEvid. Based Complement. Altnernat. Med.2013:413092,(2013)
Chen, J., Duan, M., Zhao, Y., et al.Saikosaponin A inhibits influenza A virus replication and lung immunopathologyOncotarget6(40),42541-42556(2015)
Wei, Z., Wang, J., Shi, M., et al.Saikosaponin a inhibits LPS-induced inflammatory response by inducing liver X receptor alpha activation in primary mouse macrophagesOncotarget7(31),48995-49007(2016)
Mao, X., Miao, G., Tao, X., et al.Saikosaponin a protects TBI rats after controlled cortical impact and the underlying mechanismAm. J. Transl. Res.8(1),133-141(2016)
Kang, S.J., Lee, Y.J., Kang, S.G., et al.Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and γ-H2AX in colon cancer cellsOncotarget8(59),100433-100448(2017)
